Helminthic Therapy

Community

Open Source Helminth Therapy Wiki A website that aggregates all the known information about helminthic therapy, and aims to make it more available to everyone.
Autoimmune Therapies website (helminth supply company founded by Jasper Lawrence, and home of the helminthic therapy community message board)
Ovamed website (helminth supply company out of Germany)

Blogs

Helminthic Boy: Diary of a man treating his Ulcerative Colitis with TSO pig whipworm
LukECOLOGY: Diary of a man treating his Crohn's Disease with hookworms
Waiting for the Cure: Diary of a woman treating her Crohn's Disease with hookworms

Helminths in the media

List compiled by Autoimmune Therapies and used with permission.

Bloomberg BusinessWeek: A New Prescription: Parasite Eggs. Scientists test whether whipworms can fight autoimmune disorders
Discover Magazine Blog: Are Hookworks the Next Claritin?
The Guardian (UK): Gut instinct: the miracle of the parasitic hookworm
Australian Broadcasting Company: A Hookworm Saved My Life (audio interview with Jasper Lawrence)
Technology Review: Fighting Allergies by Mimicking Parasitic Worms
HDNet: "Food Allergies, A Creepy, Crawly Cure?"
House, Season 6, Episode 6: “Teamwork”
NPR: RadioLab: RadioLab Segment on Parasites with interview of Jasper Lawrence.
Australian Broadcasting Company "The World Today": Article and Podcast regarding research in Australia into the treatment of Celiac disease with hookworms
Australian Broadcasting Company Story: Hookworms for Celiac Disease
MedPod 101: Helminthic Therapy for Autoimmune Disease Interview with Jasper Lawrence, aimed at the professional healthcare worker, from med students, nurses, nurse practioners, doctors, specialists and researchers. Technical and dense. Look for the podcast titled "Helminthic Therapy for Autoimmune Disease".
Mercola: Take Control of Your Health How Parasites Trick Your Immune System Into Health
CBS News, Part II: Patients On Hookworm Therapy Swear By Treatment
CBS News, Part I: Some Turn To Hookworms To Treat Ailments
New York Times: The Worms Crawl In
Canadian Broadcasting Corporation: Project X: Immunotherapy using helminth infection with hookworms or whipworms
New York Times: IDEA LAB; The Worm Turns
New York Times: Early Fevers May Lower Allergy Risk
National Health Service Choices: Are worms key to health?
Infection Research: Parasites and the hygiene hypothesis
The Daily Telegraph (UK): Infecting patients with worms 'could hold key to treating asthma'
Washington Post: Diseases Like Mine Are a Growing Hazard
Scienceline: Why are food allergies on the rise?
Washington Post: Immune Systems Increasingly On Attack
EBiology News: Blood-sucking hookworms may harbour asthma cure
The Boston Globe: His parasite theory stirs a revolution
BBC: Parasites 'may help MS patients'
BNet: Why We Need Germs
Guardian Online: Scientists recruit worms for fight against asthma
AsthmaUK: Gut parasites linked to reduced asthma risk
Science Daily: Could Stem Cells Be Used To Cure Crohn's Disease?
Tufts University: The Good Worms
Science Daily: Parasite Infection May Benefit Multiple Sclerosis Patients
Slate: Which Dirt Should Your Baby Eat? Mapping how bugs and virus help children develop immunity.

Academic research on helminths and the immune system

List compiled by Donna L. Beales, M.L.I.S., and used with permission.

1.	Trichuris suis ova therapy for allergic rhinitis: A randomized, double-blind, placebo-controlled clinical trial.
	Bager P, Arnved J, Rønborg S, Wohlfahrt J, Poulsen LK, Westergaard T, Petersen HW, Kristensen B, Thamsborg S, Roepstorff A, Kapel C, Melbye M.
	J Allergy Clin Immunol. 2009 Oct 2. [Epub ahead of print]
	PMID: 19800680 [PubMed - as supplied by publisher]
	Related articles
2.	Interactions between helminth parasites and allergy.
	Cooper PJ.
	Curr Opin Allergy Clin Immunol. 2009 Feb;9(1):29-37. Review.
	PMID: 19106698 [PubMed - indexed for MEDLINE]
	Related articles Free article
3.	Helminthic therapy: using worms to treat immune-mediated disease.
	Elliott DE, Weinstock JV.
	Adv Exp Med Biol. 2009;666:157-66.
	PMID: 20054982 [PubMed - in process]

4.	Can helminths or helminth-derived products be used in humans to prevent or treat allergic diseases?
	Erb KJ.
	Trends Immunol. 2009 Feb;30(2):75-82. Epub 2009 Jan 8.
	PMID: 19138565 [PubMed - indexed for MEDLINE]
	Related articles
5.	Roles for Inflammation and Regulatory t Cells in Colon Cancer.
	Erdman SE, Poutahidis T.
	Toxicol Pathol. 2009 Dec 17. [Epub ahead of print]
	PMID: 20019355 [PubMed - as supplied by publisher]
	Related articles
6.	Safety of hookworm infection in individuals with measurable airway responsiveness: a randomized placebo-controlled feasibility study.
	Feary J, Venn A, Brown A, Hooi D, Falcone FH, Mortimer K, Pritchard DI, Britton J.
	Clin Exp Allergy. 2009 Jul;39(7):1060-8. Epub 2009 Apr 20.
	PMID: 19400893 [PubMed - indexed for MEDLINE]
	Related articles Free article
7.	Experimental hookworm infection: a randomized placebo-controlled trial in asthma.
	Feary JR, Venn AJ, Mortimer K, Brown AP, Hooi D, Falcone FH, Pritchard DI, Britton JR.
	Clin Exp Allergy. 2009 Dec 16. [Epub ahead of print]
	PMID: 20030661 [PubMed - as supplied by publisher]
	Related articles
8.	Establishment and characterization of continuous hematopoietic progenitors-derived pig normal mast cell lines.
	Femenia F, Arock M, Leriche L, Delouis C, Millet G, Ben Hamouda N, Cote M, Alliot A, Lilin T, Pinton A, Iannucceli N, Parodi AL, Boireau P.
	Life Sci. 2005 Jul 1;77(7):808-23.
	PMID: 15896811 [PubMed - indexed for MEDLINE]
	Related articles
9.	Reduced helminth burden increases allergen skin sensitization but not clinical allergy: a randomized, double-blind, placebo-controlled trial in Vietnam.
	Flohr C, Tuyen LN, Quinnell RJ, Lewis S, Minh TT, Campbell J, Simmons C, Telford G, Brown A, Hien TT, Farrar J, Williams H, Pritchard DI, Britton J.
	Clin Exp Allergy. 2009 Sep 15. [Epub ahead of print]
	PMID: 19758373 [PubMed - as supplied by publisher]
	Related articles
10.	Do helminth parasites protect against atopy and allergic disease?
	Flohr C, Quinnell RJ, Britton J.
	Clin Exp Allergy. 2009 Jan;39(1):20-32. Review.
	PMID: 19128351 [PubMed - indexed for MEDLINE]
	Related articles
11.	Parasites represent a major selective force for interleukin genes and shape the genetic predisposition to autoimmune conditions.
	Fumagalli M, Pozzoli U, Cagliani R, Comi GP, Riva S, Clerici M, Bresolin N, Sironi M.
	J Exp Med. 2009 Jun 8;206(6):1395-408. Epub 2009 May 25.
	PMID: 19468064 [PubMed - indexed for MEDLINE]
	Related articles Free article
12.	New and emerging therapies for inflammatory bowel diseases.
	Grimm MC.
	J Gastroenterol Hepatol. 2009 Oct;24 Suppl 3:S69-74. Review.
	PMID: 19799702 [PubMed - indexed for MEDLINE]
	Related articles
13.	Mansonella perstans--the importance of an endosymbiont.
	Hoerauf A.
	N Engl J Med. 2009 Oct 8;361(15):1502-4. No abstract available.
	PMID: 19812409 [PubMed - indexed for MEDLINE]
	Related articles
14.	Obesity - extending the hygiene hypothesis.
	Isolauri E, Kalliomäki M, Rautava S, Salminen S, Laitinen K.
	Nestle Nutr Workshop Ser Pediatr Program. 2009;64:75-85; discussion 85-9, 251-7. Epub 2009 Aug 19.
	PMID: 19710516 [PubMed - indexed for MEDLINE]
	Related articles
15.	Infections and autoimmunity--friends or foes?
	Kivity S, Agmon-Levin N, Blank M, Shoenfeld Y.
	Trends Immunol. 2009 Aug;30(8):409-14. Epub 2009 Jul 28. Review.
	PMID: 19643667 [PubMed - indexed for MEDLINE]
	Related articles
16.	Exploring the immunology of parasitism--from surface antigens to the hygiene hypothesis.
	Maizels RM.
	Parasitology. 2009 Oct;136(12):1549-64. Epub 2009 May 22. Review.
	PMID: 19460185 [PubMed - indexed for MEDLINE]
	Related articles
17.	Trichuris suis excretory secretory products (ESP) elicit interleukin-6 (IL-6) and IL-10 secretion from intestinal epithelial cells (IPEC-1).
	Parthasarathy G, Mansfield LS.
	Vet Parasitol. 2005 Aug 10;131(3-4):317-24.
	PMID: 15978725 [PubMed - indexed for MEDLINE]
	Related articles
18.	Review series on helminths, immune modulation and the hygiene hypothesis: the broader implications of the hygiene hypothesis.
	Rook GA.
	Immunology. 2009 Jan;126(1):3-11. Review.
	PMID: 19120493 [PubMed - indexed for MEDLINE]
	Related articles Free article
19.	The hygiene hypothesis and psychiatric disorders.
	Rook GA, Lowry CA.
	Trends Immunol. 2008 Apr;29(4):150-8. Epub 2008 Mar 6.
	PMID: 18328783 [PubMed - indexed for MEDLINE]
	Related articles
20.	The hygiene hypothesis and the increasing prevalence of chronic inflammatory disorders.
	Rook GA.
	Trans R Soc Trop Med Hyg. 2007 Nov;101(11):1072-4. Epub 2007 Jul 9. Review.
	PMID: 17619029 [PubMed - indexed for MEDLINE]
	Related articles
21.	Therapeutic colonization with Trichuris suis.
	Summers RW, Elliott DE, Weinstock JV.
	Arch Pathol Lab Med. 2006 Dec;130(12):1753; author reply 1753-4. No abstract available.
	PMID: 17149943 [PubMed - indexed for MEDLINE]
	Related articles
22.	Infection with a helminth parasite attenuates autoimmunity through TGF-beta-mediated suppression of Th17 and Th1 responses.
	Walsh KP, Brady MT, Finlay CM, Boon L, Mills KH.
	J Immunol. 2009 Aug 1;183(3):1577-86. Epub 2009 Jul 8.
	PMID: 19587018 [PubMed - indexed for MEDLINE]
	Related articles
23.	Helminths and the IBD hygiene hypothesis.
	Weinstock JV, Elliott DE.
	Inflamm Bowel Dis. 2009 Jan;15(1):128-33. Review.
	PMID: 18680198 [PubMed - indexed for MEDLINE]
	Related articles Free article
24.	Early exposure of infants to GI nematodes induces Th2 dominant immune responses which are unaffected by periodic anthelminthic treatment.
	Wright VJ, Ame SM, Haji HS, Weir RE, Goodman D, Pritchard DI, Mohamed MR, Haji HJ, Tielsch JM, Stoltzfus RJ, Bickle QD.
	PLoS Negl Trop Dis. 2009;3(5):e433. Epub 2009 May 19.
	PMID: 19436745 [PubMed - in process]
	Related articles Free article
25.	Microbial exposure early in life regulates airway inflammation in mice after infection with Streptococcus pneumoniae with enhancement of local resistance.
	Yasuda Y, Matsumura Y, Kasahara K, Ouji N, Sugiura S, Mikasa K, Kita E.
	Am J Physiol Lung Cell Mol Physiol. 2010 Jan;298(1):L67-78. Epub 2009 Sep 25.
	PMID: 19783640 [PubMed - indexed for MEDLINE]
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26.	Parasitic infection and autoimmunity.
	Zandman-Goddard G, Shoenfeld Y.
	Lupus. 2009 Nov;18(13):1144-8. Review.
	PMID: 19880560 [PubMed - indexed for MEDLINE]
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